In vitro cell transformation is a valuable approach for studying the mechanisms of multistep carcinogenesis of human cells. Since immortalization is an essential step for in vitro neoplastic transformation of human cells, this study addresses the question of whether mutant p53 contributes to the imm
Increased assembly of cytoskeletal proteins associated with the transformation of human liver cells into fibroblast-like cells
β Scribed by A. Tsukamoto; Y. Kaneko; K. Kurokawa
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 591 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract It has been previously demonstrated that human carcinomas express interleukinβ2 receptor (ILβ2R) Ξ±, Ξ², and Ξ³ chains. The Ξ² and Ξ³ chains of ILβ2R have intermediate binding affinity for ILβ2 and are responsible for the intracellular signaling cascades after ILβ2 stimulation. ILβ2RΞ± lacks
We introduced the mutant p53 zene (codon 273Ar9-His) into human fibroblasts (SUSM-I ceils) previously immortalized with 4-nitroquinoline I -oxide (4NQO) and obtained 2 clonal cell lines (SUSM-I /p53-I and SUSM-l/p53-6) expressing the mutant p53. Since the genetic background of SUSM-l/p53 is the same