Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction
โ Scribed by Gabriel Moran; Virginia A. Buechner-Maxwell; Hugo Folch; Claudio Henriquez; Juan S. Galecio; Barbara Perez; Cristian Carrasco; Miguel Barria
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 316 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0165-7380
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๐ SIMILAR VOLUMES
We evaluated phenotype and apoptotic status of normal CD4 ุ CD69 ุ and CD8 ุ CD69 ุ peripheral blood T-lymphocytes after short-term challenge with escalating concentrations of phytohemagglutinin (PHA). The frequency of CD69-coexpressing CD4 ุ and CD8 ุ T-cells and CD69 staining intensity increased f
## Abstract ## Background In cancer, tumor escape from the host immune system includes apoptosis of circulating CD3^+^CD8^+^ effector T lymphocytes. Here, we compare sensitivity to apoptosis of virusโ with tumorโspecific circulating CD8^+^ T cells in patients with head and neck cancer. ## Methods
The antigenic specificity of the majority of T lymphocytes in the peripheral blood is determined by the combination of a and p variable region chains present in the T cell receptor complex. Currently, the Vp chains are grouped into 25 families. Historically, determination of Vp usage has relied on d