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Increased activity of a phospholipid base-exchange system by the differentiation of neoplastic cells from the nervous system

✍ Scribed by L. J. Erkell; G. E. de Medio; K. Haglid; G. Porcellati

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
315 KB
Volume
5
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The activity of a base‐exchange enzyme system, specific for the polar headgroups of brain phospholipids, was measured in both C 1300 mouse neuroblastoma (clone 41 A3) and human glioma 138 MG cell lines. This base‐exchange is thought to occur between free nitrogenous bases and membrane‐bound phospholipids. The incorporation of free ^14^C‐labeled ethanolamine and L‐serine was determined in undifferentiated and morphologically differentiated cells. Both cell lines showed a significant increase in ethanolamine and L‐serine incorporation upon differentiation.

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