Increased 1,25-dihydroxyvitamin D in patients with generalized scleroderma andnoaberrant calcifications
โ Scribed by J. Serup; H. K. Hagdrup
- Book ID
- 104764588
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 177 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0340-3696
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## Background: Although topical 1,25-dihydroxyvitamin d3 (calcitriol, 1, 25(oh)2d3) and its analogues, calcipotriol and tacalcitol, are effective for patients with psoriasis, some patients show little or no response. there is a need to develop more potent analogues of 1, 25(oh)2d3. hexafluoro-1,25(
la,25-Dihydroxyvitarnin D3 (10-l2 M to M) caused a dose dependent increase in PKC activity in the solubilized membrane fractions of cultured human keratinocytes and in the cytosolic fractions of cultured human fibroblasts. Maximum activity was induced by 1 a,25-dihydroxyvitamin D3 at 24 h. Sphingosi