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Increase of the anti-HIV activity of D4T in human T-cell culture by the use of the sate pronucleotide approach

✍ Scribed by Jean-Luc Girardet; Christian Périgaud; Anne-Marie Aubertin; Gilles Gosselin; Andre Kirn; Jean-Louis Imbach


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
216 KB
Volume
5
Category
Article
ISSN
0960-894X

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## Abstract We have previously shown that inhibition of the proteolytic activity of the proteasome induces apoptosis and suppresses essential functions of activated human CD4^+^ T cells, and we report now the detailed mechanisms of apoptosis following proteasome inhibition in these cells. Here we s