Methylglyoxal induces apoptosis in Jurka
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Jun Du; Haruhiko Suzuki; Fumihiko Nagase; Anwarul A. Akhand; Toshihiro Yokoyama;
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Article
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2000
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John Wiley and Sons
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English
⚖ 227 KB
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Methylglyoxal (MG) is a physiological metabolite, but it is known to be toxic, inducing stress in cells and causing apoptosis. This study examines molecular mechanisms in the MG-induced signal transduction leading to apoptosis, focusing particularly on the role of JNK activation. We first confirmed