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Increase of RhoB in γ-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells

✍ Scribed by Chun-Ho Kim; Misun Won; Chung-Hae Choi; Jiwon Ahn; Bo-Kyung Kim; Kyung-Bin Song; Chang-Mo Kang; Kyung-Sook Chung


Book ID
116299588
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
478 KB
Volume
391
Category
Article
ISSN
0006-291X

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Methylglyoxal (MG) is a physiological metabolite, but it is known to be toxic, inducing stress in cells and causing apoptosis. This study examines molecular mechanisms in the MG-induced signal transduction leading to apoptosis, focusing particularly on the role of JNK activation. We first confirmed