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Increase of Dihydrofolate Reductase Activity in Cultured Mammalian Cells after Exposure to Methotrexate

✍ Scribed by B. L. Hillcoat, V. Swett and J. R. Bertino

Book ID
123648108
Publisher
National Academy of Sciences
Year
1967
Tongue
English
Weight
907 KB
Volume
58
Category
Article
ISSN
0027-8424

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The effect of incubations with anti-sense phosphorothioate oligonucleotides directed toward sequences of dihydrofolate reductase (DHFR) RNA has been tested on Chinese hamster ovary cells. The selected targets were the 5'-untranslated region, the translational start, the splice sites and branch point