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Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea

โœ Scribed by William H. Lewis; Jim A. Wright

Book ID
118309343
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
459 KB
Volume
60
Category
Article
ISSN
0006-291X

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Hydroxyurea-resistant Aedes albopictus mosquito cells were selected by incremental exposure of unmutagenized cells to hydroxyurea concentrations ranging from 0.1 to 8 mM. Clonal populations that had become 40-fold more resistant to hydroxyurea than wild-type cells varied in morphology, and their gro