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Increase of a nerve growth factor-like protein in the cerebellum of PCD mutant mice

✍ Scribed by Joan P. Schwartz; Bernardino Ghetti; Lewis Truex; Michael J. Schmidt

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
437 KB
Volume
8
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Several areas of mouse brain (cerebellum, brain stem, and hemispheres) contain levels of nerve growth factor (NGF) detectable by radioimmunoassay. However, this immunoactive NGF is not biologically active in the chick embryo sensory ganglia bioassay. Cerebellum from pcd mice, in which neuronal degeneration elicits a glial response, contains increased amounts of NGF immunoactivity. These results suggest that CNS glia may produce a NGF‐like protein for CNS neurons.

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