𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Increase in the proportion of cells with the C'3 receptor in Balb/c mice bearing mammary tumors

✍ Scribed by Mireille Dorizzi; Gabriel Ortiz-Muniz; Diana M. Lopez; M. Michael Sigel; Robert S. Epstein

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
487 KB
Volume
16
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Transplantation of mammary tumors originally induced by dimethylbenzanthracene caused splenomegaly and an increase in the total population of spleen cells paralleling the increase in tumor size. At least part of the hypercellularity was due to in situ proliferation as evidenced by the increased number of blast forms and mitotic figures. The cells were characterized with respect to parameters generally associated with B‐cells; surface immunoglobulins as detected by immunofluorescence and C'3 receptors as determined by rosette formation with sheep red blood cells (SRBC) coated with rabbit anti‐SRBC and mouse complement. There was no change in the percentage of B‐cells with surface immunoglobulin in tumor‐bearing mice compared with the control animals. However, there was a profound change in the representation of cells bearing C'3 receptors. The percentage of the cells increased dramatically with tumor growth. Various possibilities regarding the nature and function of these cells are considered.

📜 SIMILAR VOLUMES

The effects of hyalurodinase upon tumor
The effects of hyalurodinase upon tumor formation in BALB/c mice painted with 7,12-dimethylbenz-(a)anthracene
✍ Andrew Pawlowski; Herbert F. Haberman; I. Aravindakshan Menon 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 370 KB

## Abstract Experiments were performed to investigate the effects of hyaluronidase on chemical carcinogenesis. Two experiments were carried out using BALB/c mice. In the first experiment the mice were divided into three groups, viz. (1) painted with 7, 12‐dimethyl‐benz(__a__)anthracene (DMBA), (2)

Effect of parity regimen on the rate of
Effect of parity regimen on the rate of occurrence of mammary tumors in a, C3H, and RIII mice
✍ Dr. Dan H. Moore; Jane A. Holben 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 373 KB 👁 1 views

## Abstract The occurrence rates of mammary tumors as affected by breeding regimen (early in life, late, continuous, or not at all) in A, RIII, and C3H mice were observed. The response to the breeding regimen was different in each of the three strains. The C3H stock was affected least, although the

Alteration of the systemic antitumor act
Alteration of the systemic antitumor activity of melphalan by sodium cyanate in MOPC-460D myeloma-bearing BALB/C mice
✍ George Shenouda; Maureen Hutchinson; Adrian Noë; Dr. Lawrence Panasci 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB

Sodium cyanate is a selective inhibitor of protein synthesis in a variety of mammalian tumor cells without a corresponding effect on normal tissue of the tumor-bearing animals. In the present study, we investigated the potential role of sodium cyanate in the augmentation of the antitumor activity of