𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of hyalurodinase upon tumor formation in BALB/c mice painted with 7,12-dimethylbenz-(a)anthracene

✍ Scribed by Andrew Pawlowski; Herbert F. Haberman; I. Aravindakshan Menon

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
370 KB
Volume
23
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Experiments were performed to investigate the effects of hyaluronidase on chemical carcinogenesis. Two experiments were carried out using BALB/c mice. In the first experiment the mice were divided into three groups, viz. (1) painted with 7, 12‐dimethyl‐benz(a)anthracene (DMBA), (2) injected with hyaluronidase and painted with DMBA and (3) injected with saline and painted with DMBA. In the second experiment the mice were divided into three groups: (1) painted with DMBA, (2) injected with hyaluronidase and painted with DMBA and (3) injected with heat‐inactivated hyaluronidase and painted with DMBA. The tumor incidence and size of tumors were significantly lower in the group treated with hyaluronidase than in the other groups. The latent period was increased. The mitotic index of the skin adjacent to the tumors at the end of the experiment was decreased. These studies show that hyaluronidase can act as an anticarcinogenic agent.

📜 SIMILAR VOLUMES

Deregulated expression of the PCPH proto
Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene
✍ Montserrat Solanas; Eduard Escrich; Ana Rouzaut; Irmgard Costa; Alfredo Martínez 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB

## Abstract The __PCPH__ proto‐oncogene was identified by its frequent activation in Syrian hamster fetal cells exposed to 3‐methylcholanthrene. We previously isolated human __PCPH__ cDNA and studied its expression in normal human tissues. We report herein the pattern of __PCPH__ expression in norm

Effect of wheat bran fiber on the develo
Effect of wheat bran fiber on the development of mammary tumors in female intact and ovariectomized rats treated with 7,12-dimethylbenz(a)anthracene and in mice with spontaneously developing mammary tumors
✍ Maija H. Zile; Clifford W. Welsch; Margaret A. Welsch 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 49 KB 👁 3 views

We examined the effect of consumption of graded increases of dietary fiber (soft white wheat bran) on the development of mammary gland carcinomas in intact female Sprague-Dawley rats during the promotion stage of carcinogenesis, induced with 7,12-dimethylbenz(a)anthracene (DMBA). The percent of rats

On the mechanism of hormone action in 7,
On the mechanism of hormone action in 7, 12 dimethylbenz(A) anthracene-induced mammary tumor. I. Prolactin and progesterone effects on estrogen receptor in vitro
✍ Gordon H. Sasaki; Dr. Benjamin S. Leung 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10