## Abstract ## BACKGROUND The treatment of malignant brain tumors is hampered by the presence of the bloodβbrain barrier, which limits chemotherapy penetration to the central nervous system (CNS). In recent years, different strategies have been designed to circumvent this physiologic barrier. The
Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy
β Scribed by Shailendra Joshi; Aysegul Ergin; Mei Wang; Roberto Reif; Jane Zhang; Jeffrey N. Bruce; Irving J. Bigio
- Book ID
- 106481830
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 438 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0167-594X
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## Abstract ## BACKGROUND. Cerebral metastases are clinically significant in 10% to 30% of patients with neoplasia. Multiple cerebral metastases are typically treated with palliative radiotherapy. There is no consensus on the role of enhanced chemotherapy delivery as an adjuvant treatment modality
## Abstract ## BACKGROUND. The rate of durable responses in embryonal and certain germ cell tumors of the central nervous system (CNS) is unsatisfactory. Intraarterial chemotherapy and osmotic bloodβbrain barrier disruption (IA/BBBD) increases drug delivery to the CNS. ## METHODS. Data of patien
The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening of the blood-brain barrier (BBB) for the treatment of malignant brain tumors when administered across multiple centers.
The infiltrates of intracerebrally inoculated DBLA-6 leukemia cells of the rat were used as an experimental model of meningeal leukemia in acute leukemia. Systemic administration of an antileukemic agent (daunomycin) started at the early stage of the leukemic involvement in the arachnoid, when the b