InBr3-catalyzed stereoselective synthesis of 3,4-disubstituted hexahydro-1H-furo[3,4-c]pyran derivatives
✍ Scribed by Reddy, B.V. Subba; Reddy, M. Ramana; Sridhar, B.; Reddy, C. Suresh
- Book ID
- 124118928
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- French
- Weight
- 642 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4039
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During our on-going program dealing with the asymmetric synthesis of biologically active compounds, we previously reported the efficient and enantiomerically selective synthesis of 3-substituted piperidines (2a), 3 and 3-substituted piperazines (2b) 4 by diastereoselective alkylation of chiral non-r
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## Abstract An efficient synthesis of 3‐bromoacetyl‐4‐hydroxy‐6‐methyl‐2__H__‐pyran‐2‐one by bromination of dehydroacetic acid in glacial acetic acid is described. Novel 4‐hydroxy‐6‐methyl‐3‐(2‐substituted‐thiazol‐4‐yl)‐2__H__‐pyran‐2‐ones have been prepared from the reaction of 3‐bromoacetyl‐4‐hyd