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Inactivation of the Integrin-Linked Kinase (ILK) in osteoblasts increases mineralization

✍ Scribed by Jad El-Hoss; Alice Arabian; Shoukat Dedhar; René St-Arnaud

Book ID
116320385
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
82 KB
Volume
42
Category
Article
ISSN
8756-3282

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## Abstract Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a process mediated by the α~v~β~3~ integrin. Following engagement with the ECM, integrin receptors signal via multiple downstream effectors, including the integrin‐linked kinase (ILK). In orde