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Inactivation of the hutchinson strain of non-A, non-B hepatitis virus by combined use of β-propiolactone and ultraviolet irradiation

✍ Scribed by Dr. Alfred M. Prince; Wolfgang Stephan; Herbert Dichtelmüller; Betsy Brotman; Tellervo Huima

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
857 KB
Volume
16
Category
Article
ISSN
0146-6615

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✦ Synopsis

A beta-propiolactone/ultraviolet irradiation procedure (beta PL/UV) has been evaluated for its ability to inactivate 30,000 chimpanzee infectious doses of the Hutchinson strain of non-A, non-B (NANB) virus. The chimpanzees were inoculated with plasma to which this dose of the titrated virus had been added prior to application of the beta PL/UV process in accordance with a procedure used for licensed blood derivatives in Germany. Neither animal developed hepatitis. When subsequently challenged with the same contaminated plasma, which had not been sterilized, both animals promptly developed typical NANB hepatitis. This study extends the high (approximately 10(7)-fold) process efficiency of the beta PL/UV procedure previously reported for hepatitis B virus to a blood-borne NANB virus.

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