𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents

✍ Scribed by Esteller, Manel; Garcia-Foncillas, Jesus; Andion, Esther; Goodman, Steven N.; Hidalgo, Oscar F.; Vanaclocha, Vicente; Baylin, Stephen B.; Herman, James G.


Book ID
121206093
Publisher
Massachusetts Medical Society
Year
2000
Tongue
English
Weight
487 KB
Volume
343
Category
Article
ISSN
0096-6762

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Inhibition of DNA repair and the enhance
✍ Oskar S. Frankfurt πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 841 KB

## Abstract DNA damage was evaluated by flow cytometric (FCM) analysis of cells treated with L‐phenylalanine mustard (L‐PAM) and stained with anti‐DNA monoclonal antibody (MAb) F7–26. DNA damage was rapidly repaired, as indicated by the loss of DNA immunoreactivity after removal of L‐PAM. Two types

Acquired resistance of melanoma cells to
✍ Markus Christmann; Matthias Pick; Hermann Lage; Dirk Schadendorf; Bernd Kaina πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 172 KB

Acquired resistance to antineoplastic agents is a frequent obstacle in tumor therapy. Malignant melanoma cells are particularly well known for their unresponsiveness to chemotherapy; only about 30% of tumors exhibit a transient clinical response to treatment. In our study, we investigated the molecu

Polymorphisms in MGMT and DNA repair gen
✍ James Doecke; Zhen Zhen Zhao; Nirmala Pandeya; Shahram Sadeghi; Mitchell Stark; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 French βš– 112 KB πŸ‘ 2 views

## Abstract Rates of adenocarcinoma of the esophagus (EAC) and esophago‐gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro‐esophageal acid reflux and smoking, are potentially genotoxic through the generation of __N__‐nitroso compounds. The DNA repair