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Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

✍ Scribed by Tetsuzo Nakayama; Katsuya Hirano; Mayumi Hirano; Junji Nishimura; Hirotaka Kuga; Katsuya Nakamura; Shosuke Takahashi; Hideo Kanaide


Book ID
113487150
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
454 KB
Volume
68
Category
Article
ISSN
0006-2952

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## Abstract Thrombin increases the cytosolic Ca^2+^ concentrations and induces NO production by activating proteinase‐activated receptor 1 (PAR~1~) in vascular endothelial cells. The store‐operated Ca^2+^ influx is a major Ca^2+^ influx pathway in non‐excitable cells including endothelial cells and