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Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated receptor 1

✍ Scribed by Jonathan R.S. Day; Kenneth M. Taylor; Elaine A. Lidington; Justin C. Mason; Dorian O. Haskard; Anna M. Randi; R. Clive Landis

Book ID: 113760472
Publisher: CTSNet
Year: 2006
Tongue: English
Weight: 272 KB
Volume: 131
Category: Article
ISSN: 1097-685X
DOI: 10.1016/j.jtcvs.2005.08.050

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## Abstract Factor Xa (FXa) elicits intracellular signaling responses through the activation of protease‐activated receptor 2 (PAR2) and possibly also through PAR1 in endothelial cells. In this study, we investigated FXa signaling in endothelial cells when the protease was either in free form or as