Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove
✦ LIBER ✦
Inactivation of O6-methylguanine-DNA methyltransferase in vivo by SN2 alkylating agents
✍ Scribed by Ewa Śledziewska-Gójska
- Book ID
- 116157948
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 557 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0921-8777
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