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Inactivation of Crystalline Pepsin

✍ Scribed by STEINHARDT, JACINTO


Book ID
109515197
Publisher
Nature Publishing Group
Year
1936
Tongue
English
Weight
230 KB
Volume
138
Category
Article
ISSN
0028-0836

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Alkylperoxy radicals containing one, two or three chlorine atoms, 'CO;, 0, '\_ and HO, ' were reacted with pepsin in aqueous solutions. It was found that only Cl,COO' and 'CO; inactivate pepsin, attacking preferentially the disulfide bridge. Transient spectra obtained upon completion of the Cl,COO'

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It is well known that soluble globular proteins spread on quiescent gas-liquid interfaces to form two-dimensional monomolecular films of unfolded molecules. Since the bubbling of a gas through a liquid results in the rapid formation and collapse of gas-liquid interfaces, it is to be expected that su