Inactivation of Crystalline Pepsin
β Scribed by STEINHARDT, JACINTO
- Book ID
- 109515197
- Publisher
- Nature Publishing Group
- Year
- 1936
- Tongue
- English
- Weight
- 230 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/138074b0
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π SIMILAR VOLUMES
Alkylperoxy radicals containing one, two or three chlorine atoms, 'CO;, 0, '\_ and HO, ' were reacted with pepsin in aqueous solutions. It was found that only Cl,COO' and 'CO; inactivate pepsin, attacking preferentially the disulfide bridge. Transient spectra obtained upon completion of the Cl,COO'
It is well known that soluble globular proteins spread on quiescent gas-liquid interfaces to form two-dimensional monomolecular films of unfolded molecules. Since the bubbling of a gas through a liquid results in the rapid formation and collapse of gas-liquid interfaces, it is to be expected that su