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Inactivating Mutations of KILLER/DR5 Gene in Gastric Cancers

✍ Scribed by Park, Won Sang (author);Lee, Jong Heun (author);Shin, Min Sun (author);Park, Jik Young (author);Kim, Hong Sug (author);Kim, Young Sil (author);Park, Cho Hyun (author);Lee, Sang Kyu (author);Lee, Sug Hyung (author);Lee, Shi Nae (author);Kim, Hyang (author);Yoo, Nam Jin (author);Lee, Jung Young (author)

Book ID: 119756378
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 296 KB
Volume: 121
Category: Article
ISSN: 0016-5085
DOI: 10.1053/gast.2001.28663

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Loss of heterozygosity (LOH) observed in human tumors strongly suggests the existence of (a) tumor-suppressor gene(s) at the concerned locus. A series of studies has revealed that LOH on the long arm of chromosome 5 (5q) frequently occurs in differentiated gastric adenocarcinomas. Furthermore, it ha