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Inactivating mutations of the Siah-1 gene in gastric cancer

✍ Scribed by Kim, Chang Jae; Cho, Yong Gu; Park, Cho Hyun; Jeong, Seong Whan; Nam, Suk Woo; Kim, Su Young; Lee, Sug Hyung; Yoo, Nam Jin; Lee, Jung Young; Park, Won Sang


Book ID
110069176
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
239 KB
Volume
23
Category
Article
ISSN
0950-9232

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Loss of heterozygosity (LOH) observed in human tumors strongly suggests the existence of (a) tumor-suppressor gene(s) at the concerned locus. A series of studies has revealed that LOH on the long arm of chromosome 5 (5q) frequently occurs in differentiated gastric adenocarcinomas. Furthermore, it ha