The safety of a plasma-derived hepatitis-B vaccine inactivated by two heating steps (90 sec at 103 "C followed by 10 hr pasteurization at 65 "C) was validated in chimpanzees; 1 O3 chimpanzee-infectious doses (CID,,) of hepatitis-B virus (HBV), subjected to the purification steps during production of
Inactivated hepatitis A virus vaccines
β Scribed by Stanley M. Lemon
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 538 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## **Hepatitis A virus (HAV), the causative agent of type A viral hepatitis, is an ancient human virus that was first identified almost 35 years ago. It has several characteristics that make it unique among the** **Picornaviridae** **, particularly in terms of its mechanisms of polyprotein process
Hepatitis A virus (HAV) strain HAV/HFS/GBM was adapted to and grown in human diploid fibroblast cells. The HAV was concentrated by ammonium sulphate precipitation and high-speed centrifugation. The virus was inactivated by beta-propiolacton and purified by sedimentation through a 20% solution of suc
Hepatitis B virus (HBV) is an infection with highest prevalences in Asia and sub-Saharan regions of the world where temperatures may vary widely, and where cold storage is not readily available. These are also regions where universal vaccination against HBV infection is essential to break the long-s
## Abstract The aim of this study was to predict the longβterm protection induced after immunisation with inactivated, aluminiumβfree virosome hepatitis A vaccine. The study population consisted of adult volunteers enrolled in four different clinical trials. Lower 95% confidence interval limits and
Hepatitis A virus (HAV) strain CR326, adapted to grow in LLC-MK2 cells, was highly purified, inactivated with formalin, adsorbed to alum, and tested for capacity to induce antibody to HAV in both mice and marmosets. The minimum dose of HAV antigen necessary to produce antibody in 50% of mice was 10