IN1 Molecular biology of AML
✍ Scribed by G. Stüssi
- Book ID
- 114339865
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 66 KB
- Volume
- 82
- Category
- Article
- ISSN
- 1040-8428
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The AML1/EVI-1 chimeric gene is generated by the t(3;21)(q26;q22) translocation and plays a pivotal role in progression of hematopoietic stem cell malignancies such as chronic myelocytic leukemia and myelodysplastic syndrome. In AML1/EVI-1, an N-terminal half of AML1 including a runt homology domain
## Abstract AML1/RUNX1 point mutations have been identified in myelodysplastic syndrome (MDS) and MDS‐related acute myeloid leukemia (AML), or MDS/AML, and are distributed throughout the full length of __AML1/RUNX1__. Gene mutation is proposed to be one of the disease‐defining genetic abnormalities