With signalβtoβnoise ratio enhancements on the order of 10,000βfold, hyperpolarized MRSI of metabolically active substrates allows the study of both the injected substrate and downstream metabolic products __in vivo__. Although hyperpolarized [1β^13^C]pyruvate, in particular, has been used to demons
β¦ LIBER β¦
In VivoCarbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized13C-Pyruvate
β Scribed by Simon Hu; Albert P. Chen; Matthew L. Zierhut; Robert Bok; Yi-Fen Yen; Marie A. Schroeder; Ralph E. Hurd; Sarah J. Nelson; John Kurhanewicz; Daniel B. Vigneron
- Book ID
- 106571446
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 363 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1536-1632
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Hyperpolarized 13 C MR spectroscopic imaging can detect not only the uptake of the pre-polarized molecule but also its metabolic products in vivo, thus providing a powerful new method to study cellular metabolism. Imaging the dynamic perfusion and conversion of these metabolites provides additional