𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vivoandin VitroStudies of Perchloroethylene Metabolism for Physiologically Based Pharmacokinetic Modeling in Rats, Mice, and Humans

✍ Scribed by Richard H. Reitz; Michael L. Gargas; Alan L. Mendrala; Alan M. Schumann

Book ID
112266027
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
288 KB
Volume
136
Category
Article
ISSN
0041-008X

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Physiologically based pharmacokinetic mo
Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim

Physiologically based pharmacokinetic (P
Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans
✍ Olivier Luttringer; Frank-Peter Theil; Patrick Poulin; Anne H. Schmitt-Hoffmann; πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 256 KB

The objective of this study was to use in synergy physiologically based and empirical approaches to estimate the drug-specific input parameters of PBPK models of disposition to simulate the plasma concentration-time profile of epiroprim in human. The estimated input parameters were the tissue:plasma