✦ LIBER ✦

In vivo31P NMR studies of paraplegics' muscles activated by functional electrical stimulation

✍ Scribed by M. Levy; Dr. T. Kushnir; J. Mizrahi; Y. Itzchak

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 645 KB
Volume: 29
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910290111

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The bioenergetics of paralyzed muscles of spastic paraplegic patients under functional electrical stimulation (FES) was studied in vivo using ^31^P NMR. The protocol included rest, 3 min of induced tetanic isometric contraction through surface electrodes and 40 min of recovery. The continuous stimulation, the force recording and the ^31^P NMR measurements were sampled simultaneously inside the whole body imager. Normal values were found for the phosphorous metabolite ratios at rest. During contraction, prominent changes were detected including: a) accumulation of inorganic phosphate (P) accompanied by an unusually strong signal in the phosphomonoester (PME) region, b) phosphocreatine (PCr) decline, and c) a decrease in the intracellular pH. In the following recovery period the physiological state of the muscle was monitored and quantitated by ^31^P NMR. No metabolic and mechanical irreversible damage was detected in the paraplegics' muscles activated by FES under our experimental conditions.

📜 SIMILAR VOLUMES

In vivo31P NMR studies of avian dystroph

In vivo31P NMR studies of avian dystrophic muscles

✍ P. A. Narayana; J. L. Delayre; L. K. Misra 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB 👁 1 views

In vivo 31P NMR studies of normal and dystrophic pectoralis muscles of chicks were carried out in the age group of 2 to 8 weeks. It was observed that the ratios [PCr]/[Pi] and [PCr]/[ATP] were essentially the same in both normal and dystrophic muscles. The cellular pH for normal muscles however, was

31P NMR of electrically stimulated rectu

31P NMR of electrically stimulated rectus femoris muscle: An in vivo graded exercise model

✍ Gordon O. Matheson; Donald C. Mckenzie; Daniel Gheorghiu; David C. Ellinger; H. 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 655 KB

## Abstract This study reports on the development of a model for studying skeletal muscle metabolism in humans using NMR spectroscopy. Graded exercise was simulated using electrical stimulation in 10 healthy, fit subjects (mean VO~2max~ = 53 ± 4 ml. kg^‐1^ min^‐1^). The effects of varying the stimu

In Vivo functioning of creatine phosphok

In Vivo functioning of creatine phosphokinase in human forearm muscle, studied by 31P NMR saturation transfer

✍ Deborah Rees; Michael B. Smith; Judith Harley; George K. Radda 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 770 KB

3'P nuclear magnetic resonance (NMR) saturation transfer has been used to measure enzymatic flux through the creatine phosphokinase reaction in the direction of ATP synthesis in the human forearm muscle flexor digitorum superficialis. Modification of the ratio method for measurement of spin-lattice

Assessment of intracellular magnesium de

Assessment of intracellular magnesium depletion in rat striated muscle by in vivo31p nmr

✍ E. Le Rumeur; L. Le Moyec; J. C. Yvin; S. Percehais; J. D. De Certaines 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

## Abstract Previous __in vivo__ studies have demonstrated that α, β. and γ ATP chemical shifts measured by ^31^P NMR spectroscopy can be used to determine intracellular magnesium in erythrocytes, but up to now such results have not been confirmed in striated muscle __in vivo.__ We report __BATP__

Dynamics of skeletal muscle energetics d

Dynamics of skeletal muscle energetics during ischemia and reperfusion assessed by in vivo31P NMR

✍ B. Soussi; J.-P. Idström; A.-C. Bylund-Fellenius; T. Scherstén 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 689 KB

metabolic recovery after exercise and th

metabolic recovery after exercise and the assessment of mitochondrial function in Vivo in human skeletal muscle by means of 31P NMR

✍ D. L. Arnold; P. M. Matthews; G. K. Radda 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 520 KB

It has been suggested that the rate of phosphocreatine resynthesis after exercise is an index of mitochondrial oxidative metabolism in intact muscle. To investigate this hypothesis, the time courses of metabolite recovery following mild and more severe dynamic exercise of human forearm muxle were co