𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo23Na NMR studies of myotonic dystrophy

✍ Scribed by Tammar Kushnir; Tatyana Knubovets; Yacov Itzchak; Uzi Eliav; Menachem Sadeh; Lubov Rapoport; Edna Kott; Gil Navon

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
455 KB
Volume
37
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Myotonic dystrophy is an inherited multi‐system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. ^23^Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the ^23^Na and ^1^H water signals, and the fast transverse relaxation time, T~21~, determined from the triple quantum‐filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that ^23^Na NMR enables the quantitation of myotonic dystrophy progression.

πŸ“œ SIMILAR VOLUMES

Mechanism of muscle wasting in myotonic
Mechanism of muscle wasting in myotonic dystrophy
✍ Robert C. Griggs; Ralph Jozefowicz; William Kingston; K. Sreekumaran Nair; Barba πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 740 KB
Elongation of (CTG)n repeats in myotonic
Elongation of (CTG)n repeats in myotonic dystrophy protein kinase gene in tumors associated with myotonic dystrophy patients
✍ Kenji Jinnai; Toshiko Sugio; Maki Mitani; Kozo Hashimoto; Keiichi Takahashi πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 114 KB πŸ‘ 2 views

Length of (CTG)n triplet repeats in myotonic dystrophy protein kinase gene (DMPK) was estimated in tumors, normal tissues of the same organs, muscles, and leukocytes from three myotonic dystrophy (DM) patients and a non-DM patient. Using cDNA 25 as a probe, a Southern blot analysis of EcoRI- and Bgl