𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo versus in vitro assays for assessment of T- and B- cell function

✍ Scribed by Martin F. Bachmann; Thomas M. Kündig

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
885 KB
Volume
6
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.

📜 SIMILAR VOLUMES

Expression and function of 4-1BB during
Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo
✍ Wojciech Dawicki; Tania H. Watts 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB 👁 2 views

## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve

T cell dependence of B cell unresponsive
T cell dependence of B cell unresponsiveness in vitro
✍ H. Waldmann; A. J. Munro 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 694 KB

## Abstract Antigen‐specific high zone unresponsiveness to two thymus‐dependent antigens, TNP~560~KLH (2,4,6trinitrophenylkeyhole) limpet hemocyanin and TNP~6~FGG (2,4,6trinitrophenylfowl IgG), was induced __in vitro__. It was found that carrier recognition was required for its production, and