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In vivo trapping of a vinyl chloride metabolite by means of 3,4-dichlorobenzenethiol

✍ Scribed by G. Müller; K. Norpoth; W. Owzarski

Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
146 KB
Volume
42
Category
Article
ISSN
0340-0131

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Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolites in vitro and in vivo
✍ R. J. Laib; H. M. Bolt 📂 Article 📅 1978 🏛 Springer-Verlag 🌐 English ⚖ 311 KB

Rats were exposed to [1,2-14C] vinyl chloride. Liver RNA was isolated, hydrolyzed, and the nucleosides separated on Aminex-A-6. Besides the physiological bases and 1,N6-ethenoadenosine, radioactivity was also incorporated into 3,N4-ethenocytidine. Radioactive 3,N4-ethenocytidine moieties were also f