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In vivo time-dependent inhibition of human steroid 5α-reductase by finasteride

✍ Scribed by Gaochao Tian

Book ID
109388374
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
192 KB
Volume
85
Category
Article
ISSN
0022-3549

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✍ Georgianna S. Harris; Kenneth Ellsworth; Bruce E. Witzel; Richard L. Tolman 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 235 KB

Two nonsteroids, ONO-3805 and LY191704, were evaluated as inhibitors of the human and rat 5Ͱ-reductases (5ͰR). ONO-3805 was prepared in a 12-step convergent synthesis. This compound is a potent inhibitor of the human and rat 5ͰRs, with more potent inhibition seen against the rat enzymes. The inhibit