In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease
✍ Scribed by J. Mazère; C. Prunier; O. Barret; M. Guyot; C. Hommet; D. Guilloteau; J.F. Dartigues; S. Auriacombe; C. Fabrigoule; M. Allard
- Book ID
- 118490869
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 530 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1053-8119
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Immunocytochemistry for choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) was used to examine the expression of these linked cholinergic markers in human basal forebrain, including cases with early stages of Alzheimer's disease (AD). Previous neurochemical studies
SPECT images of the brain can be obtained using either 123I labelled amines or 99mTc-hexamethylpropyleneamineoxime (HM-PAO). Both materials produce images which are blood flow dominated and so appear similar in normal subjects, although the respective mechanisms of uptake are not yet finally establi