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In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson’s disease dementia

✍ Scribed by Sean J. Colloby; Sanjeet Pakrasi; Michael J. Firbank; Elaine K. Perry; Margaret A. Piggott; Jonathan Owens; David J. Wyper; Ian G. McKeith; David J. Burn; E. David Williams; John T. O’Brien


Book ID
118490282
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
522 KB
Volume
33
Category
Article
ISSN
1053-8119

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Synthesis of (R, R)123I-QNB, A spect ima
✍ J. Owens; T. Murray; J. McCulloch; D. Wyper 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 737 KB

## Abstract The high‐affinity muscarinic receptor antagonist (R,R) I‐QNB^(1)^ [(R)‐(‐)‐1‐Azabicyclo [2.2.2]oct‐3‐yl‐ (R) ‐ (+) ‐ α‐hydroxy‐α‐(4‐[^127^I]iodophenyl)‐α‐phenyl Acetate (6a)] has been labeled with iodine‐123 to give a suitable ligand for SPECT (Single photon emission computed tomography