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In vivo selectivity of anti-inflammatory drugs on COX2-COX1 and gastrointestinal ulcers in rats

✍ Scribed by OM. Laudanno; J. Cesolari; J. Esnarriaga; P. Flaherty; J. Vada; P. San Miguel; O. Bedini

Book ID: 118521405
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 356 KB
Volume: 114
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(98)80800-7

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## Abstract Chronic arthritis adversely affects glomerular function and nonsteroidal anti‐inflammatory drugs (NSAIDs) reduce electrolyte urinary excretion. In addition, both acute and chronic inflammations may alter clearance of drugs. We studied (a) the effects of inflammation on the renal functio