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Perspective Assessment of COX-1 and COX-2 Selectivity of Nonsteroidal Anti-Inflammatory Drugs from Clinical Practice: Use of Genetic Function Approximation

✍ Scribed by Zambre, Ajit P.; Ganure, Ashok L.; Shinde, Devanand B.; Kulkarni, Vithal M.


Book ID
125944510
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
120 KB
Volume
47
Category
Article
ISSN
0095-2338

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## Abstract Chronic arthritis adversely affects glomerular function and nonsteroidal anti‐inflammatory drugs (NSAIDs) reduce electrolyte urinary excretion. In addition, both acute and chronic inflammations may alter clearance of drugs. We studied (a) the effects of inflammation on the renal functio