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In vivo radioprotection by 5-aminosalicylic acid

โœ Scribed by S.K. Mantena; M.K. Unnikrishnan; Ravi Joshi; V. Radha; P. Uma Devi; T. Mukherjee

Book ID
116759379
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
694 KB
Volume
650
Category
Article
ISSN
1383-5718

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti