𝔖 Bobbio Scriptorium
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In Vivo Pulmonary Toxicity of Cellulose in Rats

✍ Scribed by Erzsébet Tátrai; Márta Brozik; Zoltán Adamis; Katalin Merétey; György Ungváry

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
838 KB
Volume
16
Category
Article
ISSN
0260-437X

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✦ Synopsis

Cellulose after a single intratracheal dose (15 mg per animal) brought about fibrosing granulomatous alveobronchiolitis and an increase of IgA production in the bronchoalveolar lavage. Fibrosing alveolitis showed moderate progression as a function of time. With different morphological methods, injury of type I pneumocytes and the incomplete repair of type I1 pneumocytes were detected. The damage of the alveolar epithelium initiated and activated a series of processes that led to definite pulmonary alterations: pulmonary fibrosis leading to the disintegration of the alveolo-capillary morphological functional unit.

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