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Combined pulmonary toxicity of diethyldithiocarbamate and lead (II) oxide in rats

✍ Scribed by Erzsébet Tátrai; Miklós Náray; Márta Brózik; Zoltán Adamis; György Ungváry

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
171 KB
Volume
18
Category
Article
ISSN
0260-437X

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✦ Synopsis

The pulmonary toxicity of sodium diethyldithiocarbamate and lead(II) oxide alone or in combination was studied in rats after a single intratracheal instillation. The lead content in the lungs and the whole blood was determined and it has been found that the clearance of lead from the lung was delayed by dithiocarbamate complex formation, which probably had a role in increased IgA levels in the bronchoalveolar fluid and the induction of local immune response. The combined exposure gave rise to calcium deposits in the lungs both extra- and intracellularly after 1 month of exposure. Both separate and combined exposure invoked permanent injury in membranes or dystrophic changes in the cytoplasm of pneumocytes, which may initiate and generate a series of events leading to fibrosing alveolitis.

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Male albino rats were intramuscularly administered a single dose of lead acetate (100 lmol/ kg b.wt). Another group of rats were injected with sodium selenite (10 lmol/kg b.wt) before lead intoxication. After 3 and 24 hours, lead treatment resulted in significant increases in acid and alkaline phosp