𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo phosphorus spectroscopy of human skin

✍ Scribed by Daryl E. Bohning; Alexander C. Wright; Kenneth M. Spicer

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
811 KB
Volume
35
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Skin ^31^P MRS measurements might detect metabolic damage from irradiation, chemotherapy, or ischemia. Although rat and cadaver data have demonstrated this potential (C. D. Cuono, et al., Wast Reconstr. Surg. 81,1–11 (1988), H. W. Klein, et al., Ann. Plast Surg. 20, 547–551 (1988)), few studies of in vivo phosphorus human skin spectra have been published (A. Zemtsov, et al., J. Dermatol. Surg. Oncol. 15, 1207–1211 (1989), A Zemtsov, et al., J. Am. Acad. Dermatol. 30, 959–965 (1994)), and those likely reflect underlying muscle as much as skin. To separate ^31^P skin and muscle spectra, we have developed a unique two‐layer β€œflotation” phantom for mapping coil sensitivity and an associated semiempirical two‐power RF depth‐resolved technique. Phantom and method have been applied in a study of 17 normal volunteers to obtain human in vivo ^31^P skin spectra uncompromised by muscle contamination and to quantitate ratios of major phosphometabolites. Skin results consistently showed low ratios of phosphocreatine (PCr) to adenosine triphosphate (ATP), high levels of phosphomonoester (PME), P~i~, and phosphodiester (PDE) relative to PCr, and demonstrated a shift in pH toward greater alkalinity, compared to that with simultaneous muscle results.

πŸ“œ SIMILAR VOLUMES

In vitro and in vivo Raman spectroscopy
In vitro and in vivo Raman spectroscopy of human skin
✍ P. J. Caspers; G. W. Lucassen; R. Wolthuis; H. A. Bruining; G. J. Puppels πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 230 KB πŸ‘ 2 views

Noninvasive techniques that provide detailed information about molecular composition, structure, and interactions are crucial to further our understanding of the relation between skin disease and biochemical changes in the skin, as well as for the development of penetration enhancers for transdermal

In vivo phosphorus NMR spectroscopy of s
In vivo phosphorus NMR spectroscopy of skin using a crossover surface coil
✍ Yuhchyau Chen; Todd L. Richards; Seth Izenberg; Robert N. Golden; David L. Willi πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 551 KB

## Abstract A modified crossover surface coil with minimal B~1~ field penetration was used for collection of skin phosphorus NMR spectra. Projection imaging experiments show that the coilsensitive volume is uniform at the phosphorus frequency, but strikingly nonuniform at s the proton frequency. Ex

In vivo MR microscopy of the human skin
In vivo MR microscopy of the human skin
✍ Hee Kwon Song; Felix W. Wehrli; Jingfei Ma πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 853 KB

## Abstract The requirements for imaging the skin are dictated by the organ's layered structure, which extends only a few millimeters from the surface and thus demands extremely high resolution in this direction. While less critical, resolution in the remaining two dimensions determines whether the