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In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996

✍ Scribed by Salah D. Kivlighn; Gloria J. Zingaro; Robert A. Gabel; Theodore P. Broten; Terry W. Schorn; Linda W. Schaffer; Elizabeth M. Naylor; Prasun K. Chakravarty; Arthur A. Patchett; William J. Greenlee; Peter K.S. Siegl

Book ID
116155257
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
871 KB
Volume
8
Category
Article
ISSN
0895-7061

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## Abstract [α‐^11^C]Benzoyl chloride was synthesized and purified by normal phase HPLC. [^11^C]MK‐996 ([^11^C]__N__‐[[4β€²[(2‐ethyl‐5,7‐dimethyl‐3H‐imidazo [4,5‐b]pyridin‐3‐yl)methyl][1,1′‐biphenyl]‐2‐yl]sulfonyl]‐benzamide), a potent and selective ligand for the AT~1~ receptor, was prepared by __N_