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In vivo overexpression of tumstatin domains by tumor cells inhibits their invasive properties in a mouse melanoma model

✍ Scribed by Sylvie Pasco; Laurent Ramont; Lydie Venteo; Michel Pluot; François-Xavier Maquart; Jean-Claude Monboisse

Book ID: 118505911
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 955 KB
Volume: 301
Category: Article
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2004.07.036

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## Abstract Antibiotic forms of tetracycline exhibit antitumor activity in some tumor models. However, their low __in vivo__ efficacy and associated morbidity limit their long‐term application in cancer therapy. This report appraises the efficacy of doxycycline (DC) and non‐antimicrobial, chemicall