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In vivo optical and PET detections of fibrillar tau lesions in a mouse model of tauopathies

✍ Scribed by Masahiro Maruyama; Jun Maeda; Bin Ji; Ming-Rong Zhang; Takashi Okauchi; Maiko Ono; Satoko Hattori; John Q. Trojanowski; Virginia M.-Y. Lee; Toshimitsu Fukumura; Makoto Higuchi; Tetsuya Suhara

Book ID: 118464745
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 72 KB
Volume: 5
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2009.04.122

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## Abstract The present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with Alzheimer's disease (AD)‐like pathology. To address this, the transgenic (Tg) mouse model of tauopathies, Tg‐__NSE/htau23,__ which expresses human tau2