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In Vivo NMR spectroscopy of lithium-7 in humans

✍ Scribed by R. A. Komoroski; J. E. O. Newton; E. Walker; D. Cardwell; N. R. Jagannathan; S. Ramaprasad; J. Sprig

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 531 KB
Volume: 15
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910150302

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The pharmacokinetics of lithium uptake was measured by ^7^Li NMR spectroscopy at 24.83 MHz in vivo in the brain and muscle of a normal subject and a patient suffering from bipolar affective disorder, using a modified General Electric Signa clinical magnetic resonance imaging system. Comparison was made to standard phantoms to estimate Li concentrations. The levels of Li in brain and muscle were similar, were typically less than the level in serum, and generally tracked the level in serum. The Li level at steady state in the brain of a patient suffering from schizoaffective disorder was measured over a 7‐month period. Substantial variation was seen, which showed some correlation with serum level. Serum level peaked about 2 h after a single 300‐mg dose at steady state, and muscle level, immediately thereafter. Brain level peaked considerably later at 4 h. Localized in vivo ^7^Li NMR spectroscopy was demonstrated by acquisition of a 125‐cm^3^ DRESS slice from the occipital region in less than 7 min. © 1990 Academic Press, Inc.

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