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In vivo MR elastography of the prostate gland using a transurethral actuator

✍ Scribed by Rajiv Chopra; Arvin Arani; Yuexi Huang; Mireía Musquera; Jeff Wachsmuth; Michael Bronskill; Donald Plewes

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
524 KB
Volume
62
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Conventional approaches for MR elastography (MRE) using surface drivers have difficulty achieving sufficient shear wave propagation in the prostate gland due to attenuation. In this study we evaluate the feasibility of generating shear wave propagation in the prostate gland using a transurethral device. A novel transurethral actuator design is proposed, and the performance of this device was evaluated in gelatin phantoms and in a canine prostate gland. All MRI was performed on a 1.5T MR imager using a conventional gradient‐echo MRE sequence. A piezoceramic actuator was used to vibrate the transurethral device along its length. Shear wave propagation was measured transverse and parallel to the rod at frequencies between 100 and 250 Hz in phantoms and in the prostate gland. The shear wave propagation was cylindrical, and uniform along the entire length of the rod in the gel experiments. The feasibility of transurethral MRE was demonstrated in vivo in a canine model, and shear wave propagation was observed in the prostate gland as well as along the rod. These experiments demonstrate the technical feasibility of transurethral MRE in vivo. Further development of this technique is warranted. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

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