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In vivo metabolites and plasma exposure of TongMai Keli analyzed by UHPLC/DAD/qTOF-MS and LC/MS/MS

โœ Scribed by Liu, Chun-fang; Qiao, Xue; Liu, Ke-di; Miao, Wen-juan; Li, Yan-jiao; Liu, Yang; Jiang, Yan-yan; Bo, Tao; Shi, Ren-bing; Guo, De-an; Ye, Min

Book ID
120335081
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
795 KB
Volume
145
Category
Article
ISSN
0378-8741

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## Abstract The metabolic profile of BAL4815, an antifungal azole drug, was determined using __in vitro__ rat hepatocyte incubations and subsequent analysis by capillary LCโ€qTofโ€MS and MS/MS including accurate mass determination. For the detection of the metabolites, a mixture of the drug and its d