𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo metabolism of lidocaine in the rat: Isolation of urinary metabolites as pentafluorobenzoyl derivatives and their identification by combined gas chromatography-mass spectrometry

✍ Scribed by R.T. Coutts; G.A. Torok-Both; L.V. Chu; Y.K. Tam; F.M. Pasutto


Publisher
Elsevier Science
Year
1987
Weight
971 KB
Volume
421
Category
Article
ISSN
0378-4347

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Acetylation and pentafluorobenzoylation
✍ R. T. Coutts; G. A. Torok-Both; Y. K. Tam; L. V. Chu; F. M. Pasutto πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 613 KB

Known and possible phenolic and primary and secondary amine metabolites of lidocaine were added to urine from drug-naive rats. These metabolites were derivatized in this aqueous medium by acetylation with acetic anhydride or by pentafluorobenzoylation with pentafluorobenzoyl chloride. The derivative