𝔖 Bobbio Scriptorium
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In vivo localized ESR spectroscopy reflecting metabolism

✍ Scribed by G. Bacic; M. J. Nilges; R. L. Magin; T. Walczak; H. M. Swartz

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
469 KB
Volume
10
Category
Article
ISSN
0740-3194

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✦ Synopsis

Localized electron spin resonance spectroscopy in Live mice was performed using a surface coil operating at 1. I GHz with sufficient sensitivity and stability to measure quantitatively the time course of the distribution, uptake, and reduction of nitroxides in selected organsfregions (liver, bladder, head) of mice. The ability to measure regional concentrations of nitroxides in vivo could be used for pharmacokinetic analysis of drugs labeled with nitroxides and for measurement of oxygen concentrations and redox metabolism. Q 1989 Academic Press, Inc.

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