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In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors

✍ Scribed by Michael D'Angelica; Howard Karpoff; Marc Halterman; Jennifer Ellis; David Klimstra; Diane Edelstein; Michael Brownlee; Howard Federoff; Yuman Fong


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
121 KB
Volume
47
Category
Article
ISSN
0340-7004

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea