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In Vivo Induced Malignant Hyperthermia in Pigs. I. Physiological and Biochemical Changes and the Influence of Dantrolene Sodium

✍ Scribed by M. P. VerburgM.D.; F. T. J. J. Oerlemans; C. A. van Bennekom; M. J. M. Gielen; C. H. M. M. de Bruyn; J. F. Crul

Book ID
115102672
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
694 KB
Volume
28
Category
Article
ISSN
0001-5172

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Dantrolene sodium is able to reduce the
Dantrolene sodium is able to reduce the resting ionic [Ca2+]i In muscle from humans with malignant hyperthermia
✍ Dr. JosΓ© R. LΓ³pez; Dr. Pablo Medina; Lorenzo Alamo πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 253 KB

Malignant hyperthermia (MH) is a hereditaly myopathy, triggered when susceptible patients are exposed to a depolarizing muscle relaxant and/or potent volatile anesthetics. We have studied the effects of dantrolene on the free [Ca2+ 1, of intercostal muscle biopsies obtained from two MH-susceptible p