Dantrolene sodium is able to reduce the resting ionic [Ca2+]i In muscle from humans with malignant hyperthermia
✍ Scribed by Dr. José R. López; Dr. Pablo Medina; Lorenzo Alamo
- Book ID
- 102537605
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 253 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
✦ Synopsis
Malignant hyperthermia (MH) is a hereditaly myopathy, triggered when susceptible patients are exposed to a depolarizing muscle relaxant and/or potent volatile anesthetics. We have studied the effects of dantrolene on the free [Ca2+ 1, of intercostal muscle biopsies obtained from two MH-susceptible patients before and after administration of dantrolene orally (2.5 mglkg for 3 days) and intravenously (1 .O mglkg 2 hours before the biopsy). The free [Ca2+], was measured by Ca2' -selective microelectrodes. The mean resting free (Ca2 +I, in the MH-susceptible muscle before dantrolene treatment was 0.42 5 0.01 pM (mean 2 SEM, n = 12). The administration of dantrolene reduced this value to 0.27 5 0.01 pM (n = 14). There was no detectable difference in the resting membrane potential after dantrolene. These results represent the first direct demonstration that dantrolene is able to reduce the resting free [Ca2 1, in skeletal muscle of MH-susceptible patients.